Cheap, safe drug shows potential to kill cancer cells

Sunday, February 11, 2007

Recent tests have shown that an inexpensive drug may be able to kill cancer cells in humans. Dichloroacetate, a drug generally used to treat rare metabolic disorders, has shown the potential to assist in the treatment of brain, lung, and breast cancers, researchers at the University of Alberta in Edmonton, Canada say.

Dr. Evangelos Michelakis of the University of Alberta in Edmonton, Canada found that that DCA causes tumor regressions in animals with human cancers. Testing showed that DCA attacked cancer cells but did not attack healthy cells.

The researchers and the Alberta Cancer Board and Capital Health do not advise the use of DCA to treat cancer yet, as clinical trials for the drugs use to treat cancer have not been performed yet.

Unlike healthy cells, cancerous cells do not convert food molecules into energy in the mitochondria. Instead, they rely on a process known as glycolysis, which takes place in the main body of the cell, while the mitochondria are “shut down”, researchers believe possibly due to the lack of oxygen supply to cells in the middle of a tumor.

This means that another key function of the mitochondria – to activate an abnormal cell’s self-destruct mechanism, apoptosis – is also blocked.

When Dichloroacetate (DCA) enters a cancer cell, it restarts the mitochondria which in turn activate apoptosis, and the cancerous cell destroys itself.

DCA is known to be relatively safe, although pain, numbness and gait disturbances may occur. The drug is also expected to be cheaper to manufacture than other drugs since there is no patent for it.

Manitoba’s flood creating hazardous conditions

Tuesday, April 14, 2009

The Red River at Winnipeg is almost clear of ice blocks and ice jamming, however there are still dangers from the Red River flood.

Ice blocks which were as high as two storey buildings were ripping out trees, fences and railway ties. “You’ll see huge pans of ice standing vertical, up to 20 feet (6.1 m) high,” said Steve Topping, an official with the provincial Water Stewardship Department. “Ice was shoved up on the shore and took out trees with a very devastating effect. It has changed people’s view of the river.”

“It is incredible, the force. One piece of ice pushed out of the river about 20 feet. You watch the force push this up right in front of your eyes,” said Dean North, of the Selkirk Golf and Country Club.

Royal Canadian Mounted Police are ticketing sight seers who are driving through road closure signs and approaching excavators, cranes and crews breaking up the ice. Vehicles, people, boats, and kayaks are getting in the way.

An eight year old boy is in critical condition after slipping on a culvert Thursday. He was pulled underwater by the speed of the flowing water and remained under for about five to ten minutes until adults could rescue him. The air ambulance supplied by Alberta’s STARS (Shock Trauma Air Rescue Society) remains in the city of Winnipeg, Manitoba.

“This is not a spectator sport. It’s not about getting the best pictures for the family albums. I know floods are seen as a bit of an event, but some of the instances I’m hearing about, people should give their head a shake, they really should,” said Steve Ashton Manitoba Emergency Measures Minister, “Those who fall into the river or get into trouble in another way would be not only endangering themselves but the emergency response crews trying to rescue them. I don’t want to see a situation … where we’re trying our darndest to prevent flooding and save lives and somebody [who] decides to go have a white-water experience ends up killing themselves.”

Early Easter Sunday morning floodwater reached the rural municipalities of St. Andrews and St. Clements north of Winnipeg. Residents were sent an evacuation advisory Good Friday, however some residents remained. Rescue efforts commenced Saturday night to find those stranded and unable to leave as their vehicles cannot travel in the swollen overland floodwaters. Some people were rescued from roof tops as entire houses were swept off of their foundations by the large ice blocks hurtling down the river.

Highways in the area remain closed. Neil Gobelle, of Manitoba Infrastructure and Transportation said to “definitely continue to watch the Red River Valley and north of the city up in the Selkirk area. Things are changing quite a bit, quite quickly, so we’ll keep an eye on those areas.”

As of Easter Sunday, Winnipeg is expected to be ice free on the Red River. The River rose 4 feet (1.2 m) in the course of 24 hours. Rain is in the forecast and the higher temperatures of 17 °C (62.6 °F) will cause melting of snow and ice.

A weather system caused by La Niña is being watched by the United States National Weather Service and its potential effects between April 16-18 for residents along the Red River Valley. “We want people to be aware there is a very real possibility of the river going higher than what is out there,” said Mark Ewens, data manager at the NWS, “To have spring floods like this back-to-back is just an unfortunate series of events that have come along to plague us this spring. We’re wanting people to understand that this is a potentially serious problem.”

Second Darwin’s sandwich shop opens in Cambridge, Massachusetts, USA

Thursday, June 2, 2005

Darwin’s Ltd. opened a second location of their sandwich shop at 1613 Cambridge Street in Cambridge, Massachusetts, in late May. It is situated across from Cambridge Rindge and Latin School. Previously limited to one location at 148 Mount Auburn Street, the second store seats approximately 30 people and sells sandwiches, coffee drinks, locally made pastries, as well as some produce and snack foods. The establishment also provides free wireless access through the WanderingWifi service. The shop plays music during the day; during this reporter’s visit to the shop, selections played ranged from David Bowie to The Strokes. The store is air-conditioned.

Key differences between the original store and the new one include the unification of the cafe and the sandwich line now behind one counter, handicap accessible restrooms, no beer or wine sold at location, and a lack of a loyal customer base. Although the recent months have been slow, business is expected to pick up with the return of Cambridge area students this autumn.

While the original location of Darwin’s was recently cited for lacking sneeze guards before the kitchen counter, according to the Cambridge Chronicle, the new Darwin’s has acrylic sheets along the front of their sandwich counter. The original Darwin’s has installed the sneeze guard at the kitchen counter the day following citation.

This article features first-hand journalism by Wikinews members. See the collaboration page for more details.
This article features first-hand journalism by Wikinews members. See the collaboration page for more details.
Australian government announces study of tax system

Monday, February 27, 2006

The Australian federal treasurer, Peter Costello, has announced a study to compare the Australian taxation system with those of other countries. It will include overall tax levels, as well as indirect tax, income tax and company tax systems. Mr Costello says that the results are intended to inform discussion of the future of the tax system.

“The aim of the study is to provide a public document that compares Australian taxes to those in other countries. This will identify those areas where Australia leads comparable countries and those areas where it lags. It will enable a focus on the most important areas,” Mr Costello said in a media release.

The study will be lead by Mr Richard (Dick) Warburton and Mr Peter Hendy. Mr Warburton is Chairman of Caltex Australia Ltd, and has been Chairman of the Board of Taxation since its inception in September 2000. According to its website, the Board of Taxation is “a non-statutory advisory body charged with contributing a business and broader community perspective to improving the design of taxation laws and their operation.”

The Australian Democrats welcomed the study but warned that nothing would be achieved without serious reform of the tax system.

“The Inquiry announced yesterday by the Treasurer may turn out to be a step in the right direction but will be a pointless exercise if it ends up being simply a ‘desktop’ report,” said Senator Murray, Democrats Tax Spokesperson.

“The problem with Mr Costello’s approach is that in contrast to the approach taken on the GST, the New Tax System, and the Business Tax System, he has seen income tax change to be solely part of the budget process. Across the whole of the political and public policy spectrum, there is strong agreement that reform is needed, not just tax cuts, and that the income tax system needs redesigning, not just fine tuning.”

Canadian woman gives birth while sitting on toilet

Friday, December 18, 2009

International media attention has been a harsh mistress for 32-year-old Heather Richard of Winnipeg, Manitoba, who gave birth on Sunday while sitting on the toilet. Richard, who believed she was barren and thus assumed she could not be pregnant, thought she was suffering from cramps and a bad bowel movement.

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“I kept getting the urge to push and just thought it was a real bad bowel movement,” Richard told the Winnipeg Sun, whose interview was picked up by the Canadian wire service. “It just fell out. I thought it was my intestines, so I’m freaking out…but then it’s a little boy.” Richard realized that the product was a baby and not her insides when its leg twitched.

Relatives of Richard’s found her hysterically crying and pointing at the toilet. “She was crying and saying, ‘Help me, get my baby out of the toilet, he’s drowning,” Keith Richard, her cousin, told the Sun. While the rest of the family was immobile by the revelation, police officers knocked on her front door; she was to be arrested due to outstanding warrants that Richard says have since been cleared.

One officer performed CPR on the baby and it was rushed to the hospital. The baby, since named Isaiah, weighed five pounds, nine ounces, and suffered a skull fracture, presumably as a result of his head hitting the toilet bowl. The baby is in stable condition and Richard is recovering from her birth at home.

The incident spread like wildfire in the Canadian and international press on Tuesday and Wednesday. When asked about the coverage, Richard told the website canoe.ca that she was embarrassed at all the fuss the story generated.

Sony refreshes VAIO brand for business and entertainment

Thursday, July 31, 2008

From the middle of July, Sony Corporation refreshed their senior laptop brand VAIO from “Video Audio Integrated Operation” to “Visual Audio Intelligent Organizer”. According to Sony Taiwan Limited, this refreshment is an attempt to relocate the laptop consuming market for business and entertainment factors.

In the “VAIO Experience 2008” press conference in Europe, Sony promoted their new product series for different populations including BZ for business, FW for home entertainment, Z for ultra-slim, and SR for complex applications.

Different with past series, Sony added “Clear Bright” screening technology for high-definition display, and “full-carbon production” features. BD-burning and Intel Centrino 2 processing technologies will be featured in all the new models. For security issue, Sony also embedded fingerprint system to prevent personal data to be stolen. Continued from TZ series, innovative designs including “Green Power Button”, “Situational Switch” are also added in newly-launched series.

“Due to consuming market differences, Sony only promoted BZ series in Europe and America but not included Asia. Although the TICA Show in Taipei will be different, functionality will be the greatest issue when a consumers choose a notebook [computer] before buying.” addressed by executives from Sony Taiwan Limited, during the “VAIO Experience 2008” press conference in Taiwan.

Brazil spots unknown tribe of indigenous people in Amazon jungle

Wednesday, June 22, 2011

Brazil has located an isolated group of indigenous, uncontacted people in the Brazilian Amazon rainforest, the Brazilian National Foundation of Indians (FUNAI) announced today.

FUNAI, a state agency, uses aerial expeditions to avoid impacting uncontacted people and invading their land. The agency’s policy is to avoid maintaining any human contact with untouched tribes.

Clearings in the Javari river valley reservation were first identified by satellite; the group’s existence was only verified later by air flights over the area. The flights established the existence of three clearings with four straw-roofed buildings, known as malocas, which may shelter over 200 Indians. Also visible were areas where crops such as bananas, maize and perhaps peanuts were apparently being grown.

FUNAI’s Javari valley coodinator told the Brazilian news agency Estado that both the croplands and the malocas “are new” and are estimated to have been used “for at most one year”.

[T]he Amazon region contains the majority of untouched tribes without any contact with the exterior in the World.

Amorim said, “[T]he Amazon region contains the majority of untouched tribes without any contact with the exterior in the World.” And he said the recent findings highlight that the Javari valley holds, “the greatest concentration of isolated groups in Amazonia”.

The newly identified group is located close to Brazil’s border with Peru in the huge Vale do Javari reservation. Fourteen known uncontacted tribes have been spotted there and up to eight more are suggested by aerial evidence. Altogether, there are about 2,000 individuals in the reservation, according to Amorim.

He said that their culture and their very survival is threatened by illegal removal of the area’s natural resources, as well as many other intrusions of civilization, but most of Brazil’s indigenous groups have not changed their languages or traditions. FUNAI estimates that the recently discovered tribe likely belongs to the pano language group.

Brazil’s indigenous peoples have tenaciously fought for their legal right to reclaim their traditional lands which were allotted to them in Brazil’s 1988 constitution stating that all indigenous ancestral lands were to have their boundaries clearly marked and returned to tribes within five years.

Virgin train crashes in England

Friday, February 23, 2007

This article features in a News Brief from Audio Wikinews:

A 9 Carriage Class 390 Pendolino train, with as many as 180 people onboard, operated by Virgin Trains has derailed and crashed in Cumbria, England.

The train was the 17:15 service from London’s Euston Station to Glasgow Central. Witnesses said that several passengers have broken bones. All but one carriage have slid down the embankment and all of the carriages were derailed. 5 people are still seriously injured in hospital, including the driver Ian Black, and 11 people altogether are still in hospital. Hospital reports early on Saturday morning indicate 1 death, 84 year old lady Margaret Masson from Glasgow.

“It’s our understanding there are a number of people injured on the train. We think there are numerous injuries,” said a spokesman for the Cumbria Fire and Rescue squad, Brian Mitchelhill.

“A train has crashed between Oxenholme and Tebay, but that is all we know at the moment. We have got two cars travelling there now and local police are attending,” said a spokeswoman for the British Transport Police.

At least twelve ambulances and at least five fire trucks are at the scene, along with 3 Royal Air Force Sea King helicopters, two mountain rescue teams and one police helicopter. The rescue effort was hampered by limited access to the remote site and poor weather conditions.

“At the moment, we have reports of various injuries, from leg injuries to back injuries and head injuries — ranging from minor to quite serious,” said an unnamed ambulance official.

“The carriage I am in is completely on its side, it did a sort of bump – and I was thinking don’t worry this fine – but then the swaying became very dramatic,” said a BBC executive, Caroline Thomson. “Where I am there are some injuries – a woman with a very badly hurt back but I suspect further up the train it’s a bit more serious.”

First reports suggested that the train hit something on the track at 20:15 near Grayrigg, between Oxenholme and Tebay, derailed and slid down an embankment. Early investigators reports say a set of points will be the primary focus of the investigation. All but one of the train’s carriages are said to have totally come off the tracks, a spokeswoman said.

So far 12 passengers have been taken to The Royal Preston Hospital, where three casualties are said to be in a “critical condition” and one serious. 3 passengers with limb injuries are at the Royal Lancaster Infirmary. People with minor injuries were taken to a nearby farm before being transferred to a Kendal hotel.

As of 22:16, Sleeper services over the affected line have been suspended. Other major services are terminating at Preston or Carlisle according to (UK) National Rail Enquires. A five mile cordon has been set up to seal the crash site as investigators from the Rail Accident Investigation Branch attempt to determine the cause of the crash.

Virgin owner Richard Branson came to the site from his holiday in Switzerland and held a press conference at a safe distance, roughly 200 meters, from the site. Branson stated that the Virgin Train Pendolino was “built like a tank”, and believed the track was to blame. All of the carriages retained their integrity and none of the windows broke. Mr Branson also praised the driver of the train for attempting to stop the train and not leaving the cockpit.

Network Rail has checked 700 sets of rail points in response to the accident, though no speed restrictions have been imposed.

British Transport Police Contact Number 0800 40 50 40

January 19th, 2019

Importance Of A Veterinarian For Keeping Your Dog In Its Pink Of Health


Besides you, who else do you suppose is the most important for your pet (s)? Well, you can easily answer this question because you love your pet so much, right? Well, another important person for your pet, apart from you is a veterinarian. This is because, he (or she) has in depth knowledge about pets as well as various ailments related to them. Therefore, you should have the contact numbers as well as address of some of the reputable vets practicing in local animal hospitals. After all its your duty to take proper care of your dog, and do whatever is necessary to keep it fit and active all day long. Suppose, your dog is ill, and you took it to a nearby vet without inquiring about his (or her) reputation, then that Tom, Dick, or Harry can hamper the health of your pet to a greater extent. So, section of vet is the the most important in this regard.

When it comes to finding a real pet lover cum veterinarian, you can ask around the people you know. Asking other pet owners is undoubtedly one of the best considerations in this respect. Also, you should always ask for his (or her) registration with the American Veterinary Medical Association (AVMA).

So, are you searching for a reputable and caring veterinarian? McLean is one of the best places to initiate with your search. Also, you can visit the American Animal Hospital Association (AAHA) accredited animal hospitals located in the region for the same.

January 18th, 2019




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